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母得志

发布时间:2018-12-14 本文来源:

1. 职称:教授

2. 学历:博士

3. 研究方向:新生儿脑损伤的基础与临床研究

4. 联系电话:+86-28-85501698

5. 电子邮箱:mudz@scu.edu.cn

6. 个人简介:

母得志,医学博士,主任医师,儿科学教授,博士生导师。1985年毕业于重庆医科大学获学士学位,1985.7-1991.8在泸州医学院儿科任住院医师及主治医师,1991.9-1996.6在华西医科大学攻读硕士和博士学位,1996.7-1998.6在北京医科大学从事博士后研究。1998.6赴美国加利福尼亚大学旧金山分校作博士后,主要致力于发育期脑损伤发病机制及干预的研究,2002年晋升为神经生物学研究员。2003年被聘为四川大学特聘教授,从事儿科学临床、科研、教学工作,对新生儿缺氧缺血性脑病的治疗具有丰富经验。目前担任四川大学华西第二医院副院长,教育部长江学者创新团队带头人,国务院政府特殊津贴获得者,四川省学术和技术带头人,卫生厅学术和技术带头人,中华医学会儿科青年委员会副主任委员,四川省儿科专委会副主任委员、新生儿学组组长等。

近年获得国家自然科学基金杰出青年科学基金1项、重点项目2项、面上项目4项,教育部长江学者与创新团队发展计划1项,教育部博士点基金2项,四川省科技厅项目4项,美国心脏病协会科学发展项目基金1项。在国内、外医学期刊发表论文200余篇,其中SCI收录论文近百篇。主编、副主编、参编学术专著11部。获国家科技进步奖二等奖1项、教育部科技进步二等奖1项、中华医学科技奖二等奖2项、四川省科技进步奖一等奖1项,及其它成果奖4项。

7. 主要科研项目:

[1]  国家杰出青年科学基金:整合素与发育期缺氧缺血脑损伤的修复重建(30825039)

[2]  国家自然科学基金重点项目:启动子结合蛋白调控早产儿脑白质损伤后髓鞘形成的新机制(81630038)

[3]  国家自然科学基金重点项目:microRNA与新生鼠缺氧缺血脑损伤的细胞自噬调控(81330016)

[4]  教育部长江学者创新团队基金:早期发育与损伤的基础与临床嵌合研究(IRT0935)

[5]  国家自然科学基金面上项目:整合素及整合素连接激酶信号通路在新生鼠缺氧缺血性脑损伤修复中的作用(31171020)

[6]  国家自然科学基金面上项目:磷酸酶PTEN信号通路调控缺氧缺血神经元生长及分化的机制(30973236)

[7]  国家自然科学基金面上项目:整合素αVβ8在新生鼠局灶性脑缺血修复中的作用(30770748)

[8]  国家自然科学基金面上项目:HIF1a 在新生大鼠脑缺血缺氧时的信号调控(30570623)

[9]  教育部博士点基金优先发展领域类:端粒酶逆转录酶对新生鼠缺氧缺血脑损伤中星形胶质细胞功能的调节(20110181130002)

[10] 教育部科学技术研究重大项目:基于同卵双胎的先天性心脏病表观遗传分子机制研究(313037)

[11] 四川省科技厅支撑项目:新生儿危重疾病防治研究(2014SZ0149)

[12] 四川省科技厅支撑项目:新生儿缺氧缺血性脑病干预体系建设(2010SZ0280)

[13] 美国心脏病协会科学家发展项目基金:Cellular mechanisms ofrepair after ischemia in the neonatal brain (0435453N)

8. 代表性论文论著:

[1]    ZhengZ, Zhang L, Zhu T, Huang J, Qu Y, Mu D. Peripheral brain-derived neurotrophicfactor in autism spectrum disorder: a systematic review and me-x-ta-analysis. SciRep. 2016, 6: 31241

[2]    ZhengZ, Zhu T, Qu Y, Mu D. Blood glutamate levels in autism spectrum disorder: asystematic review and me-x-ta-analysis. PLoS One, 2016, 11(7): e0158688.

[3]    HuangL, Zhao F, Qu Y, Zhang L, Wang Y, Mu D. Animal models of hypoxic-ischemicencephalopathy: optimal choices for the best outcomes. Rev Neurosci. 2016, Aug25. doi: 10.1515/revneuro-2016-0022.

[4]    WangYanping, Li xiaohong, Zhou Maigeng, Luo Shusheng, Liao Juan, Chelsea A Liddell,Matthew M Coates, Gao Yan qiu, Wang linhong, He Chunhua, Kang Chuyan, LiuShiwei, Dai Li, Austin E Schumacher, Maya S Fraser, Timothy M Wolock, AmandaPain, Carly E Levitz, Lavanya Singh, Mega Coggeshall, Margaret LIND, LiYichong, Li Qi, Kui Deng, Mu Yi, Deng Changfei, Yi Ling, liu ZHENG, Ma Xia, LiHongtian, Mu Dezhi*,Zhu Jun, Christopher J L Murray, Wang Haidong. Under-5 mortality in 2851Chinese counties, 1996-2012: a subnational assessment of achieving MDG 4 goalsin China. Lancet. 2016, 387(10015): 273-283.

[5]    JichongHuang, Jun Tang, Yi Qu, Li Zhang, Yan Zhou, Shan Bao,and Dezhi Mu*. Mapping the Knowledge Structure of Neonatal Hypoxic-Ischemic Encephalopathy Over the Past Decade: A Co-word Analysis Based on Keywords. JChild Neurol. 2015, Dec 10. Pii:0883073815615673

[6]    TingtingZhu, Jun Tang, Fengyan Zhao, Yi Qu, Dezhi Mu*. Association between maternal obesity and offspring Apgar score or cord pH: a systematic review and me-x-ta-analysis.Sci Rep. 2015,5:18386

[7]    DeyuanLi, Xihong Li, Jinlin Wu, Jinhui Li, Li Zhang, Tao Xiong, Jun Tang, Yi Qu,Dezhi Mu. Involvement of the JNK/FOXO3a/Bim pathway in neuronal apoptosis afterhypoxic-ischemic brain damage in neonatal rats. Plos One. 2015,10(7):e0132998.

[8]    ZhaoF, Qu Y, Liu J, Liu H, Zhang L, Feng Y, Wang H, Gan J, Lu R, Mu D. MicroarrayProfiling and Co-ex-x-pression Network Analysis of LncRNAs and mRNAs in NeonatalRats Following Hypoxic-ischemic Brain Damage. Sci Rep. 2015, 5: 13850.

[9]    GanJ, Qu Y, Li J, Zhao F, Mu D. An evaluation of the links between microRNA,autophagy, and epilepsy. Rev Neurosci. 2015 26(2): 225-37

[10]RongLuo, Qianyun Cai, Dezhi Mu. A Chinese tuberous sclerosis complex family and anovel tuberous sclerosis complex-2 mutation. Chinese Medical Journal.2015,128(1): 128-130.

[11]QianyunCai, Rong Luo, Jing Gan, Li Zhang, Yi Qu, Dezhi Mu. Kawasaki disease mimickinga parapharyngeal abscess. Medisine (Baltimore) 2015,94(17): e761.

[12]LiuH, Li J, Zhao F, Wang H, Qu Y, Mu D. Nitric oxide synthase in hypoxic orischemic brain injury. Rev. Neurosci. 2015, 26(1):105-117.

[13]Qu Y, Wu J, Chen D, Zhao F, Liu J, Yang C, Wei D,Ferriero DM, Mu D*. MiR-139-5p inhibitsHGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatalrats. Neurobiology of Disease 2014,63 :184–193.

[14]QuY, Huang X, Li Z, Liu J, Wu J, Chen D, Zhao F, Mu D*.New Avenue for ProstateCancer Treatment: miR-199a-3p Inhibits Aurora Kinase A and Attenuates ProstateCancer Growth. Am J Pathol. 2014,184(5):1541-1593.

[15]ZhaoF, Qu Y, Liu H, Du B, Mu D. Umbilical cord blood mesenchymal stem cellsco-modified by TERT and BDNF: a novel neuroprotective therapy for neonatalhypoxic-ischemic brain damage. Int J Dev Neurosci. 2014, 38c:147-154.

[16]LuoL, Chen D, Qu ,Y, Wu J, Li X, Mu D. Association between hypoxia and perinatalarterial ishemic stroke a me-x-ta-analysis. PLoS One. 2014, 9(2): e90106

[17]LuoL, Wu J, Li J, Pan L, Li D, Wang H, Mu D. Association between maternal HBsAgcarrier status and neonatal adverse outcomes: me-x-ta-analysis. J Matern FetalNeonatal Med. 2014. Sep 18: 1-10.

[18]LiJ, Qu Y(co-first author), Chen D, Zhang L, Zhao F, Luo L, Pan L, Hua J, MuD.The neuroprotective role and mechanisms of TERT in neurons withoxygen-glucose deprivation. Neuroscience. 2013;252:346-358

[19]ZhaoJ,Qu Y, Wu J, Cao M,Ferriero D, Zhang L, Mu D. PTEN inhibition prevents rat cortical neuron injuryafter hypoxia–ischemia. Neuroscience.2013;238 :242-251.

[20]ChenH, Qu Y, Tang B, Xiong T, Mu D. Role of mammalian target of rapamycin inhypoxic or ischemic brain injury:potential neuroprotection and limitations. RevNeurosci. 2012 Apr 18;23(3):279-87.

[21]ChenH, Xiong T, Qu Y, Zhao F, Ferriero D, Mu D. mTOR activates hypoxia-induciblefactor-1α and inhibits neuronal apoptosis in the developing rat brain duringthe early phase after hypoxia-ischemia. Neurosci Lett. 2012 Jan24;507(2):118-23.

[22]ZhaoF, Qu Y, Xiong T, Duan Z, Ye Q, Mu D. The neuroprotective role of TERT via anantiapoptotic mechanism in neonatal rats after hypoxia-ischemia brain injury.Neurosci Lett. 2012 Apr 25;515(1):39-43.

[23]ZhangL, Qu Y, Tang B, Zhao F, Xiong T, Ferriero D, Mu D. Integrin β8 Signaling inNeonatal Hypoxic-Ischemic Brain Injury. Neurotox Res. 2012 Nov;22(4):280-91.

[24]XiongT, Zhao J, Chen H, Zhao F, Li J, Qu Y, Ferriero D, Mu D. Involvement of theAkt-GSK-3β-CRMP-2 pathway in axonal and dendritic injury after hypoxic-ischemicbrain damage in neonatal rat. Neuroscience. 2012,216:123-132.

[25]XiongT, Chen D, Duan Z, Qu Y, Mu D. Clofibrate for unconjugated hyperbilirubinemiain neonates: a systematic review. Indian Pediatr. 2012 Jan;49(1):35-41.

[26]ZhaoJ, Gonzalez F, Mu D. Apnea of prematurity:from cause to treatment. Eur JPediatr, 2011,170:1097-1105.

[27]TangB, Qu Y, Wang D, Mu D. Targeting hypoxia inducible factor-1α: a novel mechanismof ginsenoside Rg1 for brian repair after hypoxia/ischemia brain damage. CNSNeurol Discord Drug Targets. 2011, 10(2): 235-8.

[28]Qu Y,Duan Z,Zhao F,Wei D,Zhang J,Tang B,Li J,Yang C,Mu D.Telomerase Reverse Transcriptase Upregulation Attenuates AstrocyteProliferation and Promotes Neuronal Survival in the Hypoxic-Ischemic Rat Brain.Stroke. 2011, 42(12): 3542-50

[29]LiJ, Tang B, Qu Y, Mu D. Telomerase reverse transcriptase: A novelneuroprotective mechanism involved in neonatal hypoxic-ischemic brain injury.Int J Dev Neurosci. 2011,29:867-872

[30]XiongT, Qu Y, Cambier S, Mu D. The side effects of phototherapy for neonataljaundice: what do we know? What should we do? Eur J Pediatr. 2011, 170(10):1247-55

[31]XiongT, Qu Y, Mu D, Ferriero D. Erythropoietin for neonatal brain injury:opportunity and challenge. Int J Dev Neurosci. 2011, 29(6): 583-91

[32]XiongT, Li H, Zhao J, Dong W, Qu Y, Wu T, Mu D. Hyperbaric oxygen for term newbornswith hypoxic ischemic encephalopathy. Chochrane systematic review, 2011(8).

[33]Gang Wu,JiaoGe,XupeiHuang, Yimin Hua, Dezhi Mu. Planar cell polarity signaling pathway incongenital heart diseases. J Biomed Biotechnol. 2011, 2011:589414. doi:10.1155/2011/589414.

[34]GangWu, Xupei Huang, Yimin Hua, Dezhi Mu. Roles of planar cell polarity pathways inthe development of neutral tube defects. Journal of Biomedical Science2011,18:66.