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朱军

发布时间:2018-12-14 本文来源:

1. 职称:研究员

2. 学历:硕士

3. 研究方向:重大出生缺陷分子流行病学

基于遗传与环境交互作用的出生缺陷遗传流行病学

标准化出生缺陷数据库及生物样本库建立

4. 联系电话:+86-28-85503121

5. 电子邮箱:zhujun3@163.com

6. 个人简介:

朱军,医学硕士,研究员,博士生导师。1985年本科毕业于重庆医科大学,1988年获重庆医科大学组织学与胚胎学硕士学位,2001年作为研究学者赴日本国立女性研究所从事妇幼卫生信息研究工作,2004年赴加拿大Albert大学进修流行病学和医学遗传学,2014年在澳大利亚新南威尔士大学作高级访问学者。长期致力于我国出生缺陷群体干预效果的评价研究,以数据信息和科研成果为依据,积极促进出生缺陷防控政策的转化,推动了我国政府实施了一系列出生缺陷防控措施。目前担任四川大学华西第二医院全国妇幼卫生监测办公室/中国出生缺陷监测中心主任、出生缺陷分子流行病学实验室PI、中华预防医学会出生缺陷预防与控制专委会主任委员、中国优生科学协会出生缺陷预防专委会副主任委员、中国卫生信息学会健康统计专委会副主任委员、四川省卫计委领军人才、四川省学术与技术带头人等。

朱军教授从1996年开始一直领导着国家级出生缺陷监测网络,连续动态地获得了20多年我国出生缺陷的发生状况和变化趋势,明确了我国出生缺陷防控重点,是我国政府对外公布数据的唯一来源,为我国出生缺陷防控政府决策、临床防治、基础研究提供了科学的循证依据。她在出生缺陷分子流行病学和基于遗传与环境交互作用的出生缺陷遗传流行病学研究领域具有较高的研究水平,近年获得2项国家自然科学基金面上项目以及国家973计划项目、国家十一五和十二五科技支撑计划项目等国家级、部级课题资助共12项,作为第一和通讯作者发表SCI收录论文50余篇,其中一篇发表于The Lancet(影响因子45)。主编、副主编学术专著10部。2008年获得四川省科技进步一等奖和中华预防医学会公共卫生与预防医学发展贡献奖,2013年获得中华预防医学会科学技术二等奖和中华医学会科技进步三等奖,2014年获得首届中国出生缺陷干预救助基金会科学技术杰出贡献奖等奖项。

7. 主要科研项目:

(1)     国家自然科学基金面上项目:基于心脏间隔缺损表型差异的同卵双胎DNA甲基化表观遗传学的研究(81273086)

(2)     国家自然科学基金面上项目:多环芳烃暴露对胎儿先天性心脏病的影响及其机制研究(81573165)

(3)     “十一五”科技支撑计划:以医院为基础的出生缺陷现有防治综合技术干预效果的评价研究(2006BAI05A01)

(4)     “十二五”科技支撑计划:出生缺陷信息与生物资源平台建立及群体干预技术关键问题研究(2014BAI06B01)

(5)     科技部973子课题:先天性心脏病遗传与环境交互作用研究(2010CB529502)

8. 代表性论文论著:

(1)         Coates,Yanqiu Gao, Linhong Wang, Chunhua He,Chuyun Kang, Shiwei Liu, Li Dai, Austin E Schumacher, Maya S Fraser,TimothyMWolock2,Amanda Pain2, Carly E Levitz2, Maya S Fraser2, Jonathan C Brown2,Yichong Li5, Qi Li1, Kui Deng1, Yi Mu, Changfei Deng1, Ling Yi,ZhengLiu, Xia Ma,Hongtian Li, Dezhi Mu, JunZhu&, Christopher J L Murray&, Haidong Wang.  Child Mortality in 2851 Chinese counties,1996-2012: Rapid progress but remaining inequality.Lancet, 2016; 387(10015):273-83.

(2)         Jun Zhu*, JuanLiang*, Yi Mu*, Xiaohong Li, Sufang Guo, Robert Scherpbier, Yanping Wang, LiDai, Zheng Liu, Mingrong Li, Chunhua He,Changfei Deng, Ling Yi, Kui Deng, QiLi, Xia Ma, Chunmei Wen, Dezhi Mu, Carine Ronsmans Sociodemographic andobstetric characteristics of stillbirths in China: a census of nearly 4 millionhealth facility births between 2012 and 2014. LancetGlob Health. 2016 ; 4(2):e109-18.

(3)         Nana Li, Haitao Jia, Zhen Liu, Jing Tao, SongChen, Xiaohong Li, Ying Deng,Xi Jin, Jiaping Song, Liangtao Zhang, Yu Liang,Wei Wang & Jun Zhu*. Molecularcharacterisation of phenylketonuria in a Chinese mainland population usingnextgeneration sequencing. Sci Rep. 2015;5:15769.

(4)         Chunhua He, Leni Kang, Lei Miao, Qi Li, JuanLiang, Xiaohong Li, Yanping Wang,Jun Zhu*.Pneumonia Mortality among Children under 5 in China from 1996 to 2013: AnAnalysis from National Surveillance System. PLOS ONE, 2015;10(7):e0133620.

(5)         Xiaohong Li, Zhen Liu,Ying Deng, Shengli Li,Dezhi Mu, Xiaoxian Tian, Yuan Lin, Jiaxiang Yang, Jun Li, Nana Li, YanpingWang, Xinlin Chen, Kui Deng, Jun Zhu*.Modification of the association between maternal smoke exposure and congenitalheart defects by polymorphisms in glutathione S-transferase genes.SCI report.2015;5:14915.

(6)         Jing Tao, Nana Li, Haitao Jia, Zhen Liu,Xiaohong Li, Jiaping Song, Ying Deng, Xi Jin, Jun Zhu* .Correlation between genotype and the tetrahydrobiopterin-responsivephenotype in Chinese patients with phenylketonuria. Pediatric research. 2015;78(6):691-9.

(7)         Li NN, Chen XL, Liu Z, Li XH, Deng Y, Zhu J*. Maternal Abortion History andthe Risk of Congenital Heart Defects. A Case-Control Study.   J Reprod Med.2015, 60(5-6) :236-42

(8)         Yong Guan, Shengli Li, Guoyang Luo, ChenghongWang, Errol R. Nortwitz, Qian Fu, Xingzhi Tu, Xiaoxian Tian, Zhu J*. The role of Dopplor Waveformsin the fetal Main pulmonary artery in the prediction of neonatal respiratorydistress syndrome. J clin Ultrasound. 2015;43(6):375-83.

(9)         Liu Z, Wang J, Liu S, Deng Y, Liu H, Li N, LiS, Chen X, Lin Y, Wang H, Zhu J*. Copy number variations of GATA4 andNKX2-5 in Chinese fetuses with congenital heart disease. PediatrInt. 2015;57(2):234-8.  

(10)     Hu H, Liu Z, Li J, Li S, Tian X, Lin Y, Chen X,Yang J, Deng Y, Li N, Wang Y, Yuan P, Li X, Zhu J*. Correlation between Congenital Heart Defects and maternalcopper and zinc concentrations. Birth Defects Res A Clin Mol Teratol. 2014, 100(12):965-72.

(11)     Deng K, Qiu J, Dai L, Yi L, Deng C, Mu Y, Zhu J*. Perinatal mortality inpregnancies with omphalocele: data from the Chinese national birth defectsmonitoring network, 1996-2006.  BMCPediatr, 2014;14:160.

(12)     Li M, Liu Z, Lin Y, Chen X, Li S, You F, Deng Y, Li N, Wang Y, Zhang Y, Li X, ZhuJ*. Maternalinfluenza-like illness, medication use during pregnancy and risk of congenitalheart defects in offspring. J Matern Fetal Neonatal Med. 2014;27(8):807-811.

(13)     Dai L, Deng C, Li Y, Zhu J, Mu Y, Deng Y, Mao M, Wang Y, Li Q, Ma S, Ma X, Zhang Y.Birth weight reference percentilesfor Chinese.PLoS One. 2014;9(8):e104779.

(14)     Murray CJ, Ortblad KF, Guinovart C, Lim SS,Wolock TM, Roberts DA, Dansereau EA, Graetz N, Barber RM, Brown JC, Wang H,Duber HC, Naghavi M............ Zhu J,Zou XN, Lopez AD, Vos T. Global, regional, and national incidence and mortality forHIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for theGlobal Burden of Disease Study 2013. Lancet.2014;384(9947):1005-70.

(15)     Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS,Shackelford KA, Steiner C, Heuton KR, Gonzalez-Medina D, Barber R, Huynh C,Dicker D, Templin T, Wolock TM, Ozgoren AA, Abd-Allah F, Abera SF, Abubakar I,Achoki T, Adelekan A, Ademi Z, Adou AK, Adsuar JC........... Zhu J, Zou XN, Lopez AD, Naghavi M,Murray CJ, Lozano R. Global, regional, and national levels and causes ofmaternal mortality during 1990-2013: a systematic analysis for the GlobalBurden of Disease Study 2013. Lancet.2014;384(9947):980-1004.

(16)     Wang H, Liddell CA, Coates MM, Mooney MD,Levitz CE, Schumacher AE, Apfel H, Iannarone M, Phillips B, Lofgren KT, SandarL, Dorrington RE, Rakovac I, Jacobs TA, Liang X, Zhou M, Zhu J. Global, regional, and national levels of neonatal, infant,and under-5 mortality during 1990-2013: a systematic analysis for the GlobalBurden of Disease Study 2013. Lancet.2014;384(9947):957-79.

(17)     Li X, Zhu J*, Wang Y, Mu D, Dai L, Zhou G, Li Q, Wang H, Li M, Liang J.Geographic and urban--rural disparities in the total prevalence of neural tube defects and their subtypes during 2006--2008 in China: a study using the hospital-based birth defects surveillance system.BMC Public Health. 2013;13(1):161.

(18)     Xiaohong Li, Shengli Li, Dezhi Mu, Zhen Liu, Yanli Li, Yuan Lin, Xinlin Chen, Fengzhi You, Nana Li, Kui Deng, Ying Deng, Yanping Wang, Jun Zhu*.The association between periconceptional folic acid supplementation and congenital heart defects: A case–control study in China.Preventive Medicine.2013; 56(6):385-9.

(19)     Liu Z, Li X, Li N, Li S, Deng K, Lin Y, Chen X,You F, Li J, Mu D, Wang Y, Zhu J*.Association between maternal exposure to housing renovation and offspring withcongenital heart disease: a multi-hospital case-control study. EnvironmentalHealth. 2013;12:25

(20)     Deng K, Liu Z, Lin Y, Mu D, Chen X, Li J, Li N,Deng Y, Li X, Wang Y, Li S, Zhu J*.Periconceptional paternal smoking and the risk of congenital heart defects: Acase-control study. Birth Defects Res A Clin Mol Teratol. 2013; 97(4):210-6.